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p75 is required for NgR-mediated signalling, as neurons from p75 knockout mice are no longer responsive to myelin and to each of the known NgR ligands.
Patients and their families, grieving but desperate to make sense of the event, would find that their doctors and nurses were no longer responsive or available.
In light of encouraging results in mouse studies, we are now testing this approach at Memorial Sloan Kettering in patients with chronic lymphocytic leukemia and acute lymphoblastic leukemia who are no longer responsive to chemotherapy.
ETTH is self-limiting, but children and their parents generally consult doctors when headaches occur frequently and are no longer responsive to analgesics.
The policies related to freshwater conservation are likely to become obsolete or no longer responsive to new and changing environmental and political conditions (Woodward et al. 2010; Slate 2014).
But that promise, that potential, is being squandered by an alliance of various interests that are no longer responsive to the people.
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This may complicate therapy as the tumor may no longer be responsive to treatment with a single inhibitor which targets the original oncogene responsible for malignant transformation as the cells now have additional downstream signalling pathways activated.
Record companies are no longer as responsive, and it is easy and sometimes proper to censure their crassness.
Demands for term limits and for campaign-finance reform reflect the shared belief that government is no longer as responsive as it ought to be, at least to the needs of ordinary voters.The impeachment debacle shows what happens when a republican form of government can drag out what would have been resolved by a simple vote in a parliamentary democracy.
Perhaps more important, future studies would benefit from protocolized timing of echocardiography in relationship to fluid administration, perhaps immediately after receipt of the initial 30 ml/kg volume expansion, and again immediately when surrogates of cardiac preload indicate that the patient is no longer fluid responsive.
All patients with AIED had periods of rapid hearing loss and were no longer steroid responsive.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com