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At the time of sampling at the non-permissive temperature, however, cells were no longer replicating their DNA (Figure 1A) although the signal for gene de-repression could have been generated during chromosome replication.
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When telomeres get too short, a cell can no longer replicate, and ultimately dies.
No matter what Starbuck's flavor I tried, from Colombian to Christmas Blend, I fretted that I could no longer replicate the excitement of that first sip of smooth, rich flavor.
Lately, I note, most of the essays and stories I write tend to be broken up into very short, numbered sections, because I can no longer replicate on the page the impression or sensation of consecutive, concentrated thought, because I don't really do that anymore.
When the caps are gone, the cell can no longer replicate.
After multiple replication cycles, the accumulation of mutations surpasses a crucial threshold beyond which the virus can no longer replicate.
Highly mutated viruses can no longer replicate, and thus technology for producing viral vectors by the complementation of defective genes using complementing cells or packaging systems is impeded by low vector yields and contamination with wild-type virus rescuants.
As these chromosomes die, and cells can no longer replicate, old or damaged cells cannot be replaced.
However, there is a limit to how many mutations can be tolerated in the viral genome before it can no longer replicate.
With differentiation, the intestinal epithelial cells no longer replicate, which coincides with a change in miRNA expression and increased levels of tumor suppressors.
We demonstrate that the novel pandemic influenza (H1N1) viruses have human virus like receptor specificity and can no longer replicate in aquatic waterfowl, their historic natural reservoir.
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