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No large-scale differences in the bacterial communities of calves that did or did not develop IBK were observed in our population.
This view is supported by genomic sequence comparison, in which there are no large-scale differences in the ~1.8 Mb sequence block encompassing the common region deleted in WBS, with the exception of an overall reversed physical orientation between human and mouse.
This difference in synteny reflects the previously documented 4AL/5AL translocation [ 13, 26] and no other large scale differences in syntenic blocks were observed.
However, there are no data to suggest large scale differences in coding or patient case mix over time or between the two groups during the study period.
After removing large scale differences possibly caused by phase unwrapping errors, we found that the height difference varied with forest cover [10], increasing about linearly from zero in non-forest areas to 2 m in forests having 100%% cover.
Small PDC values and significance thresholds are not easily visible due the large scale differences.
We also reported that this analysis was confounded by large scale differences between the study sites.
Comparisons of gene expression within the groups of vaccinated and naïve fish found large scale differences between HR and LR.
This allows for a simultaneous comparison of the individual EIPR values with their respective significance thresholds even in case of large scale differences.
S. pneumoniae, as with other bacterial pathogens, possesses a conserved core genome with interspersing regions of small and large scale differences.
An accepted method of identifying large scale differences in gene expression is to use EST abundance as an indicator of transcript abundance.
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