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Our results also suggested that the optimal spacer length for such bivalent compounds ranges from 17 to 21 atoms, and further spacer extension beyond 21 atoms results no further optimization.
The usage of CH3CN as solvent and TBAH as base led to final product amounts of 2.6 ± 1.3 GBq (method 1) or 0.76 ± 0.27 GBq (method 2), which was considered sufficient for clinical and preclinical use of the radiotracer, so that no further optimization of synthesis parameters was performed.
The refinement process is mainly determined by the results of the previous screen until no further optimization can be obtained.
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Where adding an extra mutation to the model increased this score, no further optimizations were carried out.
All the above experiments used features without any further optimization.
For a RCBD, each batch will have equal number of samples with same characteristic and there is no need for further optimization.
There is no further process optimization option parallel to production, which, in the case of small molecule productions, allows further process optimization.
Further optimization is required.
This would require a further optimization.
Our software automates tour scheduling and incorporates network partners for further optimization.
A parametric study is conducted for further optimization.
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