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Assuming that the no further linkage of cases was possible, the private laboratory reports contributed to a maximum of 44 cases (equivalent to nine cases/year) in addition to the MRU-confirmed cases over the 5-year period (30 HESonly, 10 unlinked, 4 HES+/MRU-).
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However, to avoid any possible mistake, we also repeated the search using husband's name; no further linkages were found.
Apart from the ERCP procedure using the same duodenoscope, the review of the medical records did not develop any further linkage between the patients from wards A and B and the four single CRKP cases.
An indication of the importance of these discoveries at that time is that, even though each of these papers went no further than reporting (loose) linkage to markers, two of them were published in Nature Genetics and the other in PNAS& As the numbers of markers increased, Charlier et al.
The physico-chemical surface modifications, related with a modified morphology, an increased polarity and a higher level of surface oxidation, may be favorable to the further linkage of selected biological species relevant in medical usages.
Further linkage disequilibrium analyses indicated these 3 SNPs were in linkage (r2>0.8).
Further linkage analysis was performed on enz using haploid genomes, or meioses [62].
SNP rs11218942 (G > T> C) is triallelic and was not analyzed in further linkage disequilibrium analysis and tagSNPs selection.
Further linkage to VEGF can be inferred from the finding that low dose simvastatin induces phosphorylation of Akt which is a critical pathway in endothelial cell survival and angiogenesis [37].
We selected phenotypes that showed significant heritability for further linkage studies (Table 3), namely: number of P. falciparum clinical attacks (PFA), the mean of parasite density during clinical attacks (me-PFD), prevalence of asymptomatic infection (PtPF) in both villages, the mean and the maximum (me-tPFD and mx-tPFD, respectively) asymptomatic parasite density.
These two markers are dropped from further linkage analyses.
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