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The p.A46T was predicted by the software to potentially affect protein function, whereas the p.R334H was predicted to have no functional effect.
Two human MR-angiography studies found no functional effect of intravenously infused PACAP38 on the MCA but a 17 19% and 2 h sustained dilation of the middle meningeal artery (MMA) in healthy volunteers [4] and migraine patients [5].
Two novel intronic variants were identified which likely have no functional effect.
While nitroso-L-cysteine had a similar effect to NONOates, nitroso-D-cysteine had no functional effect on myosin, showing stereospecificity for the endogenous NO donor.
It is possible that the low level of SOD expression in B. neotomae is sufficient to inactivate the host-derived superoxide radicals and any additional increase in the amount of SOD has no functional effect.
We also noted that the two protective haplotypes H2 and H5 did not carry KIR2DS4, whereas the risk-associated haplotype (H1) carried the deleted form, resulting in the production of a truncated protein predicted to have no functional effect [34], [35].
Similar(36)
Normally, this heterogeneity may have no functional effects and escape detection with commonly used analytical procedures.
In addition, splice variants in the non-coding 3'-UTR were described, but no functional effects were detected on 5-HT biosynthesis by them [34].
Nuclear hormone receptor binding sites next to important CTCF sites at the Igf2/H19 locus have been found, but no functional effects with respect to insulation, enhancer blocking or imprinting could be shown [19].
No functional effects of the variant have been reported.
No predictable morphological changes correlated with these differences and, as described below, no functional effects could be correlated to the variable clusterin expression levels.
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