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Specifically, elevated levels of NO disrupt the redox activity of protein-disulfide isomerase, a key endoplasmic reticulum-resident chaperone by S-nitroso modification of its redox-active cysteines.
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Thought we talked about this folks, no disrupting traffic.
Flitch also tweeted: "We talked about this folks, no disrupting traffic" — a comment which was promptly ridiculed on social media.
We observed that the interrupted PPE genes were PPE16, PPE34, PPE38, PPE40 and PPE49 in several points and in both orientations and there were no disrupted PE genes (Additional file 1: Table S4).
Nitric oxide (NO) can disrupt tight junctions and gap junctions, and NO and NO synthases (NOS1 NOS3) were upregulated in mutant white matter.
As NO disrupts ER calcium pump activity and induces ER stress, we tested the role of HBHA on NO synthesis in macrophages.
NO disrupts at least in part the effect of Ca2+ on cell phospholipid membrane scrambling [ 218] and by nitrosylation of enzymes [ 217].
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