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Because there is no correlate of protection, however, human studies will be necessary to evaluate vaccine efficacy prior to deployment.
The exception to this is pertussis, for which no correlate of protection currently exists.
However, no correlate of vaccine efficacy (VE) has yet been established.
This signature focused on the interferon response and immune signalling, but likewise no correlate of pathogenicity was identified.
As no correlate of protection is established for B. pertussis, a vaccine response to this vaccine component was defined.
The clinical relevance of the observed differences remains unknown, especially for antigens with no correlate of protection.
Similar(48)
Clinical correlates of a greater glucose excursion suggest that it reflects a decreased capacity for insulin secretion, whereas no correlates of the triglyceride excursion were identified.
Furthermore, development of protection after BCG vaccination cannot be assumed by the formation of a scar; there are no correlates of BCG protection.
However, there is as yet no immunological correlate of protection and no functional assays or animal models that have demonstrated the ability to predict efficacy in humans.
As yet there remains no accurate correlate of protection for malaria sporozoite challenge [15], [18], [50], [51].
Although this does not compromise the data, it shows that there is no single correlate of stress providing full discriminant validity and unaffected by contaminating factors [64].
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CEO of Professional Science Editing for Scientists @ prosciediting.com