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To date, no convincing trial addresses this clinically challenging question, likely because of the very low breakthrough rates observed [ 4– 6].
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Israel has also demanded the extradition of Mr. Zeevi's killers, but officials have suggested that they would settle for a convincing trial and monitored incarceration.
The first convincing trial results from a single 15-microgram dose in adults were published online Thursday afternoon by The New England Journal of Medicine.
The doctors and scientists are dismayed that the WHO has not yet revised its advice, in spite of a very large and convincing trial they carried out, the results of which were published in May 2011 in the New England Journal of Medicine.
162 A meta-analysis of three randomized, double-blind, placebo controlled trials by McGuinness and colleagues reported that there was no convincing evidence from the trials that BP lowering in hypertensive patients prevented the development of dementia or cognitive impairment.
A Cochrane review [ 31] concludes that " There was no convincing evidence in the reviewed trials to suggest that lowered blood pressure prevents the development of dementia or cognitive impairment in hypertensive patients without manifest prior cerebrovascular disease".
Their review of nimodipine [ 5] found the methodological quality of the animal studies was poor, and that only 50%% of the studies were in favour of the intervention with no convincing evidence to start clinical trials which had involved thousands of patients.
To date, no convincing preclinical studies and clinical trials demonstrating systemic effects following local PRP injections are reported and, as showed by Dhillon et al., this is probably due to the limited need of PRP injections in clinics and the short in vivo half-lives and local bioavailability of GFs produced by PRP [ 168].
In the bigger, well-designed trials, there was "no convincing evidence" that homeopathy was more effective than a placebo, they found.
In the bigger, well-designed trials, there was "no convincing evidence" that homeopathy was more effective than a placebo, they found.This is all true.
The news that probiotic drinks don't really do anything for you – a review of seven major trials has found "no convincing evidence" that they have any effect at all on the gut bacteria of healthy people – is the kind of story that gladdens my heart a little.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com