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NO competes with oxygen in binding to cytochrome oxidase (complex IV), thereby decreasing the activity of the enzyme.
NO competes with oxygen binding at the cytochrome c oxidase, the terminal acceptor in the mitochondrial electron transport chain.
At low concentrations, NO competes directly with oxygen at cytochrome c oxidase, and reversibly negatively regulates this complex (Brown 2001).
NO competes with molecular oxygen at Complex IV of the electron-transport chain, leading to impaired oxidative phosphorylation and ATP generation, which can induce dysregulation of cellular Ca2+ homoeostasis resulting in endoplasmic reticulum stress [ 36– 36].
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