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The co-adsorption of NO and oxygen suggested that oxygen and NO compete for the same part of copper sites.
Because arginase and NOS (NOS converts arginine to NO) compete for cellular arginine as substrate, an inhibition of arginase activity might favor NO synthesis.
Physiological levels of nitric oxide (NO) compete with O2 for cytochrome oxidase when [O2] is low, effectively raising the apparent Km of this enzyme [ 32– 35], and may thus alter the local [O2] around mitochondria, leading to changes in O2− production [ 36– 36].
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Karen Lehrmann Ægidius reports no competing interests.
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