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Thus, older RBC units may retain NO, causing vasoconstriction and venous stasis, which may increase the risk of thrombosis.
Similarly, in an endothelin 1-mediated pathway that was recently described in endothelial cells, the endolysosome contributes to activation of downstream ER pathways, eventually stimulating endothelial nitric oxide synthase to produce NO, causing vascular smooth muscle to relax.
This results in uncoupling of NOS, which then produces ROS itself instead of NO, causing further oxidations – a vicious cycle leading to further impairment of endothelial function (Rubanyi and Vanhoutte, 1986; McIntyre et al., 1999).
However, this response to NMDA, and that occurring in vivo (Faraci & Breese, 1993), was nullified by tetrodotoxin, implying that the NO causing the vasodilatation is not produced directly by NMDA receptor stimulation but through a secondary, action potential-dependent mechanism.
Furthermore, it has been suggested that ROS produced during reperfusion react with and downregulate the bioavailability of NO causing medullary vasoconstriction [36].
In 8 patients no causing microorganism could be identified.
Similar(49)
They advance no causes".
This vindicates the slogan "no causes in, no causes out" (Cartwright 1989, Ch. 2).
Japan no longer causes much alarm.
No cause was specified.
No cause was disclosed.
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