Your English writing platform
Discover LudwigExact(2)
The recombinant T. gondii enzymes exhibited an absolute requirement for biopterin for activity using the stable tetrahydrobiopterin analog 6-MPH4 (6-methyl-tetrahydropterin) At concentrations <20 µM 6-MPH4 no catalysis was observed.
In the example discussed above, if the catalytically active protein evolved from a protein whose role required no catalysis in an earlier period of evolutionary history, then His12 may not have been present in that period, even though its absence in a modern protein might cause disease.
Similar(58)
NO-Remediation Catalysis Test: The NO-remediation reaction was performed over the catalyst in a circulating-gas reactor equipped with a gas chromatograph (Shimadzu GC-8A).
No homogeneous catalysis was detected in the filtered liquid media obtained after contact with the solids.
In neuronal cells of developing rat brain, Pb has been shown to adversely influence the activity of an enzyme, nitric oxide (NO) synthase (nNOS), responsible for catalysis of NO synthesis, which could be considered as another mechanism of neurotoxicity caused by lead.
Based on the expectation that the complete 20s loop is necessary for catalysis, no dehydration activity was detected for HsrTSβ.
Despite finding the conserved second-coordination sphere Glu/Asp important in catalysis, no mechanistic insight was gained from these studies.
Although the superposition of RNase H of XMRV with HIV-1 RT showed good potential contact between the side chain of Arg and the phosphate backbone of the RNA template, the R609A mutation had no influence on catalysis.
Here, we present the complex structure of Rap Rap1GAP in the GDP-BeFx-bound state at a resolution of 3.4 Å, showing that the 'Asn-thumb' occupies the position of the catalytic glutamine residue in those other systems, and that Thr61 of Rap has no role in catalysis.
From the structure, this residue is predicted to have no role in catalysis or in DNA binding as the distance from R260 to the adenine-binding pocket is >16 Å. Future screening for hMYH associated mutations in cancer should also include R260Q.
The homotrimer of 23 kDa subunits has no cofactor requirements for catalysis.
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com