The difference among the distances-variations between each pair of markers, instead, could be addressed to the residual deformation of the canvas, inherited from nighttime HR changes, which reached the peak value of 60%.
Overall, exenatide was not associated with significant changes in mean 24-hour, daytime, or nighttime HR within or between groups.
In addition, only exposure levels above Lnight (8-hr nighttime noise level) 50dBB [ Lden (combined day-evening-night noise level) 55 dB] were available, so health impacts could not be estimated for lower exposure levels.
BP measurements were automatically measured every 20 minutes during the daytime and every 30 minutes during the nighttime over a 24-hr period.
We computed 24-hr and nighttime values of the standard deviation of all normal RR (NN) intervals (SDNN), which are summary measures of HRV, as well as the following frequency domain variables: total power (TP) (≤ 0.40 Hz), low-frequency (LF) power (0.04 0.15 Hz), high-frequency (HF) power (0.15 0.40 Hz), and the LF/HF ratio.
Finally, there were strong associations between HRV during the nighttime hours and both the SS source category and the RS source category that were not seen for HR at the other intervals, or for HRV at the other time periods.
In contrast, nighttime associations were nearly null at 1-hr and 4-hr and positive at 8-hr, 3-day, and 5-day.
Although the lag between exposure (during the workday) and outcome (during the nighttime) was less than 24 hr in the present study, it is still biologically plausible that responses occur within a range of time from exposures.
Out of the 19 variables tested, 9 showed an association with EBF cessation; of these, two had never been evaluated in Brazilian studies, namely, mother partner's appreciation for breastfeeding (hazard ratio [HR] 0.62; 95% confidence interval [95% CI] 0.48-0.79) and limiting the number of nighttime feeds at the breast (HR 1.58; 95% CI 1.11-2.23).
In another study, 12 weeks of exenatide treatment in patients with type 2 diabetes was associated with a trend towards lower 24-hr, daytime, and nighttime systolic blood pressure, but had no clinically meaningful effect on heart rate, compared with placebo [ 53].
