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We propose that E-cadherin orchestrates multiple aspects of stem cell behavior, including polarization of stem cells toward the stem cell-niche interface and adhesion of stem cells to the niche supporting cells.
Communication between stem and niche supporting cells maintains the homeostasis of adult tissues.
Rab8a global knockout (Rab8a −/−) presumably affected Wnt secretion from all niche supporting cells.
Moreover, the satellite cells are markedly affected by their niche, supporting that transplantation of these cells in young patients will result in better outcomes than in old patients.
It has recently been reported that the NOTCH1 receptor is expressed by cardiac progenitor cells (CPC), and that its ligand JAG1 is expressed by their niche supporting cells in the mouse heart.
These effects are mediated in part by changes in the somatic gonad (Yang and Yamashita, 2015), including changes in the size of the somatic niche supporting germline stem cells (Bonfini et al., 2015; Hsu and Drummond-Barbosa, 2011).
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Music has worked like this for decades; bands writing songs that appeal to a small niche and that niche supports the close circle of bands and musicians who play that particular style of music.
The endosteal niche supports chemoresistant leukemic stem cells [9] and is thought to be rich in fibronectin and hypoxic [10].
In this case, it cannot be overlooked that an impairment in the maintenance of undifferentiated spermatogonia can be caused by a malfunction of the stem cell niche supported by Sertoli cells.
The enrichment of several TF-binding motifs in genes that are overexpressed in the prostate stem cell niche supports the notion that this is a self-renewing primitive compartment (Table 3).
The niche supports two stem cell populations that compete for niche occupancy.
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