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Even if water is not the growth limiting factor in vivo, it may still be possible in future to treat acne via niche disruption once we understand more about P. acnes adaptation to its ill-defined follicular habitat.
Recently, progress in biology knowledge has resulted in a large number of targeted therapies, designed against surface markers, cell signaling pathways, cell cycle and apoptosis machinery, key molecules involved in cellular metabolism, in proteasome, and in immune modulation, and niche disruption.
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Glioma stem cells (GSCs) are known to be maintained within a "vascular niche"; thereby, disruption of this microenvironment using antiangiogenesis agents is a promising therapeutic modality.
Wearables was a niche that needed disruption but, in the end, will be further disrupted by the biggest players in the market.
Muse cells exist in a quiescent state under normal physiological circumstances within the cellular niche prior to cellular stress disruption [24, 26].
Alterations in microtubule network organization in vRGCs and a disruption of cortical niche architecture, including altered expression of cell adhesion molecules, are also observed.
The human pathogen H. pylori developed efficient strategies to colonize the gastric epithelium as a unique niche, where it induces the disruption of the epithelial layer contributing to inflammatory diseases (e.g. chronic gastritis, ulceration), mucosa-associated lymphoid tissue (MALT) lymphoma and gastric cancer in humans [1], [2].
(2010) identified that S. epidermidis can displace S. aureus from the nasal niche by serine protease-mediated biofilm disruption; Lina et al.
Such a disruption or "defect" is called a niche (Fig. 1) [ 7].
"The more, the merrier" approach to species richness produced resilient communities, enabling efficient nutrient uptake due to niche complementarity and eliminating process downtime due to biological disruptions.
Meanwhile, worries about supply chain disruptions have prompted others to buy certain niche products in large quantities, and a reworking of widely used "just in time" manufacturing methods to account for those shifts could raise prices globally.
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