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As apps get richer and interactive devices become more intuitive and ubiquitous, the mouse/keyboard combo is becoming more and more a niche control scheme.
Therefore, CSCs might arise from normal stem cells that have acquired mutations that enable them to escape from niche control.
Thus, the osteoblastic cells in the skull niche control hematopoiesis including megakaryopoiesis in the context of skeletal homeostasis (Pallotta et al., 2009).
Numerous reciprocal morphogenetic interactions within the renal stem/progenitor cell niche control the development of nephrons and the spatial organization of parenchyma at the right site and at the right time [ 25, 50].
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It also emphasizes the concept of a stem cell niche within a tissue and how the niche controls stem cell activity.
This niche controls the proliferation and specialization or 'differentiation' of adjacent stem cells and/or progenitor cells (Krzemień et al., 2007; Mandal et al., 2007).
Hence, two distinct types of hematopoiesis coexist in Drosophila larvae; one in the lymph glands, where a niche controls the differentiation of stem cells, and another under the skin, where a niche controls how already differentiated plasmatocytes transform into crystal cells and, when needed, lamellocytes.
Ongoing characterisation and genetic manipulation of PSC function in controlling Drosophila haematopoiesis are thus expected to provide clues as to how the mammalian bone marrow niche controls the balance between HSC self-renewal and differentiation.
A small multicellular niche controls cell states in the other two zones (Crozatier et al., 2004; Jung et al., 2005; Krzemien et al., 2007; Mandal et al., 2007), which are located up to as many as 50 cell diameters away.
In recent years, the increasing industrial demand of high quality and high efficiency machining motivates us to develop a niche active control method to mitigate the chatter dynamics with input constraints.
Biomimetic systems can be engineered to incorporate extrinsic biochemical and biophysical signals to modulate the stem cell niche, to control cell-cell and cell-matrix interaction, oxygen distribution, local pH levels and nutrient transport within organoids (Yin et al., 2016).
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