Exact(5)
Previous reports have proposed that HSCs localize to the vascular niche, comprised of endothelium and tightly associated perivascular cells.
In Drosophila testis, a group of 8 12 GSCs reside in a niche comprised of two types of somatic cells: hub cell and cyst stem cells (CySCs).
Interested in the fate of cancer cells that have successfully colonised distant sites, Ghajar and colleagues examined whether the perivascular niche (comprised of endothelial cells and their basement membrane) constitutes a niche for dormant cancer cells [ 5].
We show that in the ovary, the differentiation niche, comprised of specifically shaped ECs exists and that the shape of these cells regulates the differentiation ability of the neighboring GSC progeny.
However, the proponents of postnatal oogenesis in females propose that menopause may actually be the result of compromised somatic niche (comprised of ovarian epithelial cells), which does not allow stem cells to undergo self-renewal, differentiation, and follicular assembly to form PF in situ [ 77, 78].
Similar(55)
The niche comprises mainly Sertoli cells, cytokines and growth factors produced by Sertoli cells, peritubular myoid cells and blood vessels.
The ISC niche comprises also other cell types such as enteric neurons, intraepithelial lymphocytes, smooth muscle cells of the muscularis mucosae, lymph and vascular endothelial cells, and a variety of bone-marrow derived stromal cells [170,171].
The stem cell niche comprises several components, including resident cells that create essential structural features, provide the proper growth factor milieu to promote self-renewal and/or differentiation of the stem cells, and maintain the stem cell population without excessive proliferation [ 35].
The vascular niche is comprised of extracellular matrix (ECM) proteins such as collagen type IV, fibronectin, laminin, fibrinogen [7], [8], and most likely VWF, which allow proplatelet formation.
It may resemble the normal plasma cell niche which comprises SDF-1-producing stromal cells and that is shared with hematopoietic stem cells and pre pro B cells [ 20].
Niche 5 was comprised largely of western European countries, Japan, and South Korea, and characterized by the highest purchasing power per capita and chicken production productivity, the lowest density of agricultural population, and an intermediate density of domestic ducks and chickens.
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