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Guidelines for treatments such as this rely heavily on scientific evidence and on organisations such as the National Institute for Health and Clinical Excellence (Nice) evaluating the strength of the arguments in favour and against.
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NICE evaluates pharmaceuticals, medical devices, diagnostic techniques, surgical procedures, other therapeutic technologies and health promotion activities [ 19].
When NICE evaluated the cost-effectiveness of long-acting insulin analogues they also included a factor for fear of hypoglycaemia in the appraisal.
For instance, the British National Institute for Health and Care Excellence (NICE), besides evaluating the "clinical effectiveness" of a new technology, also performs cost-effectiveness assessments.
Nice, nice, nice.
The National Institute for Health and Care Excellence (NICE), which evaluates treatments, considers it good value.
However, expensive treatments such as OnabotulinumtoxinA are subject to approval by the NICE who evaluates the cost effectiveness and the gain in Quality Adjusted Life Year (QALY) of a treatment before recommending it.
NICE also evaluated other studies that had been published as abstracts including the FOLFOX/FOLFIRI data (Tournigand et al, 2001).
Furthermore, because the RAI was calculated based on the ICERs mainly retrieved from NICE (UK), the ranking reflects how well each country adheres to NICE's method of evaluating cost-effectiveness.
Although NICE did not evaluate docetaxel as a first line treatment option, some data exists regarding its use in this setting.
In the UK, NICE have the remit of evaluating health technologies and making recommendations to the Department of Health about whether they should be funded or not.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com