We next used titrated amounts of the blocking mAb, while keeping the peptide concentration constant (Fig. 4B).
Subjects with an ineffective response were titrated to the next higher dose (eg, 50 or 70 mg/d), provided AEs were tolerable.
The dosage was initiated at 30 mg/d of LDX and upwardly titrated to the next available dose at weekly intervals until the optimal dose was reached.
The dose was titrated to the next higher dose level if the patient had more than 3 breakthrough pain episodes requiring breakthrough pain medication within the previous 24 hours.
Treatment regimens of nateglinide and gliclazide were started at the lowest levels (60 mg three times a day before meals and 80 mg once per day, respectively) and were titrated to the next dose level on a monthly basis up to a maximum of 180 mg before meals and 240 mg per day, respectively, during the first 3 months.
Daily doses were titrated up to the next higher dose level, with no dose levels skipped, at most once a day.
Then, as reproduction proceeds over the next 3-5 days, vit mRNA levels are titrated downward in response to actual reproductive demand.
Since it has been reported that HIV-1 neutralization is target cell type-sensitive [59], [60], we next used TZM-bl as target cells and titrated the mAbs against a larger panel (n = 46) of predominantly (38/46) Tier-2 pseudoviruses (Table S2).
Before planning next study, the optimal dosage of oxytocin for gastric motility must be titrated.
4 Typically, the drug is given at a dose of 0.5 mg daily for the first 3 days, 0.5 mg twice daily for the next 4 days, and then on the eighth day (generally the scheduled quite date), the drug is titrated up to its final dose of 1 mg twice daily.
