Sentence examples for next replication from inspiring English sources

Next, replication activities of these 3'NTR mutated replicons were compared by monitoring colony forming activities in transfected cB76.1/Huh7 cells.

Spontaneous deamination of 5-methylcytosine leads to a C to T transition via uracil formation and the replacement of thymine in one of the two daughter strands during the next replication round.

In cells deficient in MGMT, O-methylguanine is not repaired and results in the incorporation of a thymine (T) residue in the complementary position at the next replication cycle.

These gaps in the genome and double strand breaks (DSBs) that form at these sites during the next replication cycle have been proposed to be mediating the cytotoxic effects of different alkylating agents [ 8].

The basis for this statement is straightforward: if the enzyme binds too tightly to nonspecific DNA sequences, the residence time will be too long to efficiently scan the entire genome before the next replication event, while if interactions are too weak, insufficient time will be spent inspecting individual DNA base pairs, leading to overlooked base lesions.

We next investigated replication efficiency ηr at various loci of the genome.

We next examined replication timing at three loci before and after neocentromere formation.

DNA lesions become mutagenic if they persist until the next DNA replication round.

We next sought replication for our top SNPs (see Table S1 in the online data supplement).

It was reported that the sticky end formed by this TNT activity is favourable for the next round replication of the dsRNA [ 17].

To further investigate the role of genetic variation in the IL2 IL21 locus in the regulation of IL-10 secretion, we next sought replication of these findings in an independent data set of CD4+ T cells stimulated with β cell-specific antigens.