Sentence examples for next generation compounds from inspiring English sources

In this study as the first attempt; comparative molecular field analysis (CoMFA), comparative molecular similarity indices analysis (CoMSIA) and AutoGPA-based 3D-QSAR methods were applied on a set of 47 recently reported Ck1d inhibitors, in order to gain an insight into the structural requirements which providing guidelines for the design of next generation compounds with enhanced bioactivity.

For their broad pharmacological application, next generation compounds require, however, improvements of their stability, selectivity, bioavailability, and/or pharmacokinetics.

Another strategy for next generation compound design may be to use moieties that block the space in the active site near His that water molecules must occupy for activation.

These drug amino functionalities represent potential sites of modification in the design of next-generation compounds that can overcome APH(3′ -IIIa-induced resistance.

Our results highlight functionally important contact points that have not been fully explored in the current HIV IN inhibitors, raising hopes that next-generation compounds can be developed based on the now available structural information.

Therefore, the effects of lenalidomide on Aiolos protein levels observed in vitro were also detected in human volunteers, suggesting that the measurement of Aiolos protein levels in peripheral blood cells can be used as a clinical biomarker of lenalidomide activity and may be used to define the dose and schedule for novel indications and next-generation compounds.

Lilly advanced a next-generation compound, LY2886721, into Phase 1 and 2 clinical trials to determine its safety and tolerability, pharmacokinetics, and pharmacodynamics.

In order for medicinal chemists to tune solubility of lead compounds, a rapid assay is needed to provide solubility data that is accurate and predictive so that it can be reliably used for designing the next generation of compounds with improved properties.

These measurements will enable better dosing and scheduling for the emerging next generation of compounds.

A next generation series of compounds were designed with improved specificity, potency against InhA, and reduced cytotoxicity in vitro, but these compounds also had limited solubility.

Here, we disclose the next generation of benzothiazinone compounds and present an optimized preclinical candidate, PBTZ169, that is highly potent against drug-susceptible and drug-resistant Mycobacterium tuberculosis.