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Doses were taken twice daily for 3 1/2 days followed by FMD and a 4-day washout before proceeding to the next dosing period.
Patients treated with 5 mg/kg or 10 mg/kg TCZ showed significant improvement by week 2. The next dosing determination trial was conducted in Japan.
After a 1-hr acclimation, animals were removed from home cages, dosed, and then returned to the home cages until the next dosing time or testing.
Escalation to the next dosing level was only allowed once these five subjects completed treatment and all results and safety data were evaluated.
For the neurotoxicity, an oxaliplatin-specific scale was used: grade 1, paresthesias or dysesthesias of short duration, but resolving before the next dosing; grade 2, paresthesias persisting between doses (2 weeks); and grade 3, paresthesias interfering with function.
Since a small amount of IgG is eliminated during DFPP, IgG in plasma was measured pre-and post-plasmapheresis and the next dosing of trastuzumab was adjusted to the amount of eliminated IgG.
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Before she could take the next dose, O.R.R. intervened.
The next dose of bad news for Texas?
Their greatest concern was finding a way to pay for their next dose.
I'd be climbing the walls that last hour while I waited for the next dose.
The lowest levels of a pharmaceutical present in the blood before the next dose.
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