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This does not automatically lead to consideration of newer targets or even newer mechanisms of action.
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Since the advent of donepezil as a treatment for AD, new mechanisms of action of this molecule have been discovered.
Due to increasing emergence of bacterial resistance, compounds with new mechanisms of action are of paramount importance.
The emergence of multidrug-resistant bacteria creates an urgent need for alternative antibiotics with new mechanisms of action.
Highly pathogenic H5N1 virus (H5N1) entry is a key target for the development of novel anti-influenza agents with new mechanisms of action.
Pharmacological interventions to reduce fracture risk are exploring new mechanisms of action, in particular the uncoupling of bone resorption and formation.
New mechanisms of action have been described, supporting the use of lower doses, possibly with the same efficacy and less adverse effects.
These novel techniques not only are illuminating the 'black box' that has obscured the pharmacodynamic effects of immunosuppressants but also are uncovering new mechanisms of action of these drugs.
The new report starts with the premise that the world needs 15 new antibiotics per decade, at least four of which should have new mechanisms of action to target the most harmful pathogens, such as Klebsiella pneumoniae and Escherichia coli.
The search for new lead compounds of simple structure, displaying highest quality anti-tumor potency with new mechanisms of action and least adverse effects is the major intention of cancer drug discovery now a days.
The paucity of anti-opportunistic drugs, the decreasing efficacy and the development of resistance against the azoles and even amphotericin B have stimulated the search for new drugs with new mechanisms of action.
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