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Every new school year brings a new progression in year group, a step up the playground pecking order.
Put simply, the invention of Bitcoin is what Matilla referred to as a "disruptive innovation", which is basically a brand new progression in technology/economics that could disrupt things so radically that we begin to behave as a society in a completely different way.
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It's essentially a remastered look at the environments from the last version with the new progression system, improved combat A.I. picture-in-picture mode and higher difficulty levels.
Although local failure rate was as low as 7.7%, a high rate of new disease was found in a study of RFA by Kosari et al. New intrahepatic disease was seen in 49% of patients, new systemic progression in 24% of patients, and concurrent progression of new intrahepatic and new systemic disease in 22% of patients [ 46].
Thus, because of its fibrogenic potential, the detection of epithelial-mesenchymal transition in biopsy specimens could be useful diagnostically and represent a new biomarker of progression in chronic fibrosing diseases.
For example, aberrantly methylated TBX4 was identified as a novel potential marker for disease progression [ 1] and Cathepsin E, Maspin, Plk1 and Survivin were proposed as new markers for progression in non-muscle-invasive bladder cancer [ 2].
In measurable disease, partial response (PR) was defined as ⩾50% decrease of the total tumour load in two observations not less than 4 weeks apart, in the absence of new lesions or progression in any existing lesion.
Progressive disease (PD) was defined as more than a 20% increase in the maximum diameter of measurable disease, or as evidence of new disease or progression in non-target lesions.
From these 4 categories, we defined 2 groups of patients; group I included those patients with equal or recurrent pathologies and group II included those patients with new findings or progression in pathologies.
These results together suggest that VHR can be considered as a new marker for cancer progression in cervix carcinoma and potential new target for anticancer therapy.
To determine if PROS plays a role in inhibiting cell cycle progression in new born neurons of the postembryonic brain, we took advantage of the fact that termination of mitotic activity in the larval OL is known to be controlled by the expression of the CKI dacapo (dap) [36].
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com