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AKR1B10 deficiency may be a new predisposition of UC and CAC.
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The application of a family-focused approach has the potential to detect many new predispositions.
This identification of linkage evidence for a new CRC predisposition locus that includes predisposition for other cancers, to date observed in 1 of 13 pedigrees (8%), could lead to identification of new genes or variants responsible for CRC and other cancers.
We report on the discovery of two new BCC predisposition loci: TGM3 and RGS22.
Additionally, understanding the molecular basis for congenital ALL may lead to novel insights into leukemogenesis and new cancer predisposition syndromes.
These data suggest that TACC3 may be a new familial predisposition or modifier locus for gynecological cancer.
The accumulated experience to date has served to highlight the difficulties in conducting statistically and methodologically rigorous association studies to identify new cancer predisposition loci.
We have added 2 new BE predisposition SNPs, rs3072 on chromosome 2p24 and rs2701108 on chromosome 12q24, to the 2 BE SNPs on chromosome 6p21 (HLA region) and chromosome 16q23 (near FOXF1) that we reported previously.
Indeed, broadly screening the variants across disease populations has uncovered multiple new genetic predispositions for familial breast cancer.
Our results suggest three new genes for predisposition to BEN pathology, related to angiogenic alterations.
Exome sequencing in 43 patients with CRC from 29 families with strong disease aggregation identified new potential CRC predisposition variants in CDKN1B, XRCC4, EPHX1, NFKBIZ, SMARCA4, and BARD1.
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