Another approach was recently developed, based on active immunotherapy, which consists of inducing Abs able to neutralize the interaction of the self-cytokine to its receptor.
The importance of the CXCR4/CXCL12 pathway in tumor development was further demonstrated by neutralizing the interaction between CXCL12 and CXCR4.
Furthermore, neutralizing the interaction between CXCL12 and CXCR4 significantly impaired metastasis to regional lymph nodes and lung in mice.
The system consists of a nonlinear controller at the first level to neutralize the interaction terms, and some adaptive controllers at the second level, in which the gains are optimally tuned using genetic algorithm.
The proposed control system consists of an adaptive backstepping controller at the first level, in which the gains are optimally and automatically tuned using genetic algorithm; and a nonlinear controller at the second level to neutralize the interaction terms.
We therefore decided to focus on peptides that mimicGPVI, and have taken advantage of a monoclonal antibody, 9O12.2, which binds GPVI with a high affinity, and neutralizes the interaction between GPVI and collagen in vitro and in vivo [13], [14].
This "antigenic drift" in HA epitopes [7] affects recognition by antibodies that neutralize viral infectivity by blocking the interaction of HA with sialic acid residues on host-cell membranes.
There are also several potential therapeutics that target some of these disease-causing pathways, for example by neutralizing the cytokines, or by blocking the interaction of T cells and antigen-presenting cells.
These changes indicate that at pH 5.6 there is a strong electrostatic interaction between GO and lysozyme, neutralizing the surface charge of GO.
IL22RA2 protein specifically binds to interleukin 22 (IL22) and by preventing the interaction of IL22 with its cell surface receptor, neutralizes IL22 activity [ 30- 32].
