However, in vivo, protection was independent of immunoglobulin subclass, avidity, neutralization rate constant, and in vitro neutralizing activity; above a minimal avidity threshold, protection depended simply on a minimum serum concentration.
In vitro, neutralizing activity correlated with avidity and with neutralization rate constant, a measure of on-rate.
Trials of candidate pre-pandemic vaccines for the H5N1 influenza virus have shown seroconversion rates (defined as having a fourfold neutralizing seroconversion rate) between 60 and 90percentnt [ 18, 20- 22].
DENV neutralizing antibody seropositivity rates and GMTs for unprimed subjects with MN50 data available are presented in Tables 6 and 7, and reverse cumulative curves are shown in Figures 3– 6.
BOTOX® exhibits a predictable response, with a concomitant low rate of neutralizing antibody formation.
Compared to EV71, significant higher positive rate of neutralizing antibody against CA16 in 2007 was identified.
Overall, 4% of the dog sera we tested contained neutralizing EVEV antibodies, a rate similar to the seroprevalence for the major human pathogenic arboviruses (EVEV, EEEV, Saint Louis encephalitis virus, Western equine encephalitis virus) in Florida detected in >2,500 sera from wildlife in 38 of the state's 67 counties from 1965 to 1974 (24 ).
Key characteristics of an ideal agent used for platform therapy are maximal efficacy, safety, tolerability, convenience, and low rates of neutralizing antibody formation (neutralizing antibodies formed in the body may block or neutralize the biologic effects of the foreign protein or polypeptide, potentially decreasing the therapeutic effects of these agents) (Stuart et al. 2004).
Results : Doses from 27,476 IU to 587 IU induced similar seroconversion rates and neutralizing antibodies geometric mean titers (GMTs).
Different prevalence rates of neutralizing antibodies to the 3 chimpanzee adenoviruses in human samples from the 3 African countries tested may reflect different infection rates in chimpanzees residing in these areas.
