PROBLEM: Neutralizing antibodies (inhibitors) against the therapeutic clotting factor prevents factor replacement therapy and increases morbidity and mortality in haemophilia.
The host immune response may also be problematic: with viral gene transfer agents, recognition of viral coat proteins and the production of neutralizing antibodies leads to problems with re-administration.
This is compounded by the fact that few aesthetic clinicians, particularly non-physician injectors, are familiar with the problem of neutralizing antibodies and will continue to treat with a higher dose or by switching to another therapy.
G. vaginalis caused infections continue to be a world-wide problem, therefore neutralizing recombinant antibodies may provide novel therapeutic agents useful in the treatment of bacterial vaginosis and other diseases caused by G. vaginalis.
G. vaginalis caused infections continue to be a world-wide problem, therefore neutralizing recombinant antibodies may provide novel therapeutic tools useful in the treatment of BV and other diseases caused by G. vaginalis.
The present work, therefore, evaluates the performance of potential neutralizing chemicals to address the problem of acidic water of the Kopili River.
However, long-term studies are needed to investigate whether, at long term, neutralizing antidrug antibodies will pose a problem for efficacy and safety of blocking CGRP with monoclonal antibodies.
This problem needs to be addressed by further understanding the mechanisms of neutralization and finding the desired neutralizing site during membrane fusion.
This does of course not exclude the possibility that repeated injections of IdeS in humans, as is the case with streptokinase, may cause problems in some patients due to neutralizing antibodies or allergic reactions.
Many consider antigens associated with or anchored in the gut membrane of blood-feeding nematodes as "hidden" (41), i.e., not continuously presented to the immune system, with the concomitant problem of rapid waning of the neutralizing antibody response due to the lack of a "natural boost".
