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Taken together, our data shows that the TRF2 N-terminus promotes the intrinsic ability of nucleosomal arrays to fold into more compact structures by neutralizing negative surface charge.
Analytical agarose gel electrophoresis (AAGE) studies showed that TRF2 promoted the folding of nucleosomal arrays into more compact structures by neutralizing negative surface charge.
It has been noted that the arginine residues in the AT-hook sequence PRGRP insert their side chains into the minor groove of DNA and thus contribute directly to DNA binding, while lysines flanking the AT-hook core contribute to DNA binding by neutralizing negative charges of the DNA backbone [13], [17].
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It aims to help people live in harmony with nature by promoting the flow of chi, or positive energy, and neutralizing or avoiding negative energy.
Alternatively, these 32 patients were indeed SARS patients, but the negative neutralizing antibody reading was due to patent's low antibody level in combination with the low sensitivity of the antibody test.
However, in the suramin-treated group, fewer than 20 copies of viral genomic RNA/mL were detected between days 6 and 9. EV71 neutralizing antibody was negative in all serum collected before viral challenge, monkeys involved in this study do not have pre-antibody.
Characterizing and neutralizing similar cases of negative epistasis could improve productivity in many agricultural organisms.
*POWV, Powassan virus; RT-PCR, reverse transcription PCR; CSF, cerebrospinal fluid; IFA, immunofluorescent assay; MIA, microsphere immunoassay; PRNT, plaque reduction neutralizing test;; +, positive; –, negative.
This reduction in microvessel density and leukocyte rolling were reversed by systemic administration of a TGF-β1 neutralizing antibody, suggesting a negative role for TGF-β1 in early neovascularization.
The neutralizing titer for WNV was negative in all of these cases (data not shown).
Geometric mean IC90 neutralizing antibody titers ranged from negative (<10) to 40.
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