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Moreover, the neutralizing Mabs could more efficiently neutralize AIV H5N1 strains from the natural hosts generally, such as waterfowl.
This would explain why gp70 is a poor neutralization target and why gH/gL-specific neutralizing mAbs act mainly after binding [13].
"Reverse vaccinology" strategies start from interesting neutralizing mAbs and work backwards to design immunogens mimicking the neutralization epitopes targeted by the mAbs.
The conserved linear epitope targeted by the neutralizing mAbs (FIEGGWTGMVDGWYGYHH) is part of the fusion peptide on HA2.
Marked differences with the vaccine strain O1/Campos, including the loss of reactivity with neutralizing MAbs, were recognized.
Pharmacological EGF-R inhibiting therapy using either neutralizing mAbs or small-molecule tyrosine kinase inhibitors (TKI) has been successfully used in cancer treatment.
Particular neutralizing mAbs to certain cytokines act as agonists in vivo through protection of the cytokine's active site and prolongation of its half-life.
Competitive binding assays were conducted against known broadly neutralizing mAbs.
The three new neutralizing mAbs HJ16, HGN194 and HK20 show some interesting features.
Several new broadly neutralizing mAbs were developed targeting the CD4bs [28].
Neutralizing mAbs can block fusion [27], [35], but are quite rare in virus carriers and do not work well.
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