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Higher titer antibodies were induced, but without neutralizing activity.
The neutralizing activity of anti-GA antibodies was insignificant.
No neutralizing activity was detected in the ADA-positive study samples.
However, these antibodies had no neutralizing activity and vaccinated people were not protected from HIV infection.
Although anti-MPER antibodies were generated, antiserum did not present neutralizing activity.
The serum from immunized rabbits also had MPER-specific antibodies, but without neutralizing activity.
The serum exhibited a weak neutralizing activity for HIV-1 clade B and clade BC.
This evaluation indirectly confirms the lack of neutralizing activity of ADAs.
Additional evaluation of neutralizing activity was conducted using a cell-based assay.
You can read the research paper entitled Vector-mediated gene transfer engenders long-lived neutralizing activity and protection against SIV infection in monkeys at Nature.com.com
In parallel, we observed 7 out of the 17 had the neutralizing activity to cH5/1 SZ) pps.
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