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Numerous recent studies have shown the role of stalk-specific antibodies in neutralization of influenza viruses; the finding that stalk antibodies can effectively neutralize virus alters the existing dogma that influenza virus neutralization is mediated solely by antibodies that react with the globular head of the viral hemagglutinin.
The sera, however, failed to neutralize virus JRFL, which is sensitive to the PGT bnAbs, indicating that the binding modes of the serum antibodies and PGT nAbs differ.
Antibodies are Y-shaped proteins that neutralize virus particles by grabbing onto all the surface receptors they use to attach to cells.
To study stalk-specific antibodies, we have developed chimeric hemagglutinin constructs that enable the measurement of antibodies that bind the hemagglutinin protein and neutralize virus but do not have hemagglutination inhibition activity.
The antibodies neutralize virus particles through interactions with highly conserved CD4 receptors, which are similar or identical to each other and which are found on most strains of HIV.
We observed that 3E31 inhibits E-mediated membrane fusion, suggesting that the antibody is able to neutralize virus through binding an as-yet uncharacterized intermediate conformation of DENV E and sterically block trimer formation.
Similar(33)
Antibodies neutralize viruses by blocking their receptors and by attracting white blood cells that will engulf the virus.
Such software not only detects and removes viruses but can also catch and neutralize viruses as they come into computers, thus preventing infection.
Cerus, for example, is helping Baxter come up with a scrubber to neutralize viruses, bacteria and pathogens from the blood.
Therefore, 10E8 can neutralize viruses with a greater potency and breadth than the previously discovered 2F5 and 4E10, and it is comparable to some of the most potent bNAbs, such as VRC01 or PG9/PG16 (West et al., 2014).
Thus the viruses in this panel for the most part represented difficult to neutralize viruses.
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