A key feature of a therapeutic antibody is an ability to specifically neutralize the target without off-target effects.
They neutralize their target transcription factor, thus preventing its binding to specific regulatory sequences in the promoter of its target genes and thereby effectively inhibiting its expression.
Another avenue to neutralize a target who might be acting on behalf of a foreign power is to cut off that person's access to information that could help our adversary.
The action buttons allow participants to assign threat level and immediacy and to neutralize a target aircraft.
Using this binding mechanism, an antibody can tag a microbe or an infected cell for attack by other parts of the immune system, or can neutralize its target directly (for example, by blocking a part of a microbe that is essential for its invasion and survival).
Our data highlighted the importance of binding affinity and off-rate effect of a mAb to fully neutralize the target and how this may influence its efficacy and potentially worsen disease activity.
Consider the stark contrast between the ambiguous language used to define legitimate targets and the specific technical means a military uses to neutralize these targets.
Beginning with a campaign against the Communist Party, U.S.A., in 1956, the bureau's notorious Cointelpro programs aimed to "expose, disrupt, misdirect, discredit or otherwise neutralize" their targets.
Here, we report a rational design of PLs-decorated lipid nanoparticles (PL-NPs) for neutralizing a target toxin in vivo.
Structure of an HIV-1 Neutralizing Antibody Target: A Lipid Bound gp41 Envelope Membrane Proximal Region Trimer.
In addition, the antibodies neutralized their target, GnRH, as shown by testosterone level reduction and testis atrophy.
