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Given that TSS is characterized by a robust elevation in systemic levels of several cytokines and chemokines, neutralization of key cytokines and/or chemokines could have therapeutic potential, as in other inflammatory diseases [14], [15].
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In the field of cancer, neutralization of the key angiogenic growth factor VEGF is daily clinical practice, mostly in combination with chemotherapeutic agents.
Allied intelligence and photoreconnaissance had identified five 155-mm guns emplaced in reinforced-concrete casemates on the Pointe, and Allied commanders had determined that the neutralization of these guns was the key to the fate of the Omaha and Utah landings.
Taken together, these results suggest that the beneficial effects of TZDs on platinum-based chemotherapy are mediated through the inhibition of endotrophin in mammary tumours, and that the neutralization of endotrophin activity is a key determinant to unleash the full beneficial effects of TZDs.
Soviet doctrine during the 1970s suggested that a key aspect of that offensive would be the neutralization of NATO's nuclear assets by overrunning key installations, with a possible shift to a regional nuclear offensive when the right moment arrived.
Recently determined crystal structures of key antibodies in complex with their EBOV epitopes have provided insights into the molecular architecture of GP and defined likely hotspots for viral neutralization.
Chains of key rings.
However, sCD14 could play a key role as an intermediate in the neutralization of LPS under physiological conditions.
Although the activation of BAK may occur either directly or indirectly, a key feature of both models is the neutralization of antiapoptotic BCL-2 proteins by BH3-only proteins.
The key stability of the catalysts has been attributed to the neutralization of Lewis acid of uncovered zirconia, which are unselective coke initiator sites.
Key inclusion criteria were age <15 years, cardiac surgery involving cardiopulmonary bypass, intraoperative bleeding after neutralization of heparin, and hypofibrinogenemia.
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CEO of Professional Science Editing for Scientists @ prosciediting.com