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Among the 12 neutralising anti-BoNT/A1 mAbs, mTA12 exhibits the strongest neutralisation capacity, evaluated between 6.2 and 20.8 IU/mg, ranking this reagent as a good candidate for immunotherapeutic purposes.
Acid neutralisation capacity (ANC) at pH 7, 4 and 2 was monitored with powdered pastes.
In this study, a new method for identifying the concrete mix proportion is developed by the acid neutralisation capacity (ANC) of concrete.
The performance was assessed over time using unconfined compressive strength (UCS), hydraulic conductivity, acid neutralisation capacity (ANC) and pH-dependent leachability of contaminants.
Relevant characteristics such as setting time, unconfined compressive strength (UCS) and leaching behaviour assessed by acid neutralisation capacity (ANC), monolithic and granular leaching tests were examined in light of the UK landfill Waste Acceptance Criteria (WAC) for disposal.
Especially, the critical [Cl−]/[H+], i.e. the ratio of acid soluble chlorides to acid neutralisation capacity irrespective of the type and different sources of chloride salt approximately keeps constant at 0.02.
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Thus, raising the neutralisation capacities for IGF-2 in the space of Disse as well as blocking the IGF-1R may be interesting strategies to prevent the formation of HCC in patients at risk of developing this malignancy.
In addition, decreasing pH, usually accompanying pyrite oxidation, can be masked by the high pH-neutralisation capacity of carbonate and silicate minerals.
Compositional changes, including acid neutralising capacity, trace-metal and phosphorous binding capacities, and toxicity leaching characteristics (TCLP) show that different neutralisations produce two geochemically distinct solids, those without alkalinity precipitation, and those with solid alkalinity.
Since variability of the BoNT gene and protein sequence within botulinum neurotoxin subtypes A has been reported and these sequence variations impact on antibody binding and neutralisation [21], the capacity of mouse and chimeric antibodies to neutralise BoNT/A2 and /A3 was evaluated using a mouse neutralisation assay with 5 estimated MLD50 per mouse of each toxin subtype.
The results show that the recombinant mAb retained a capacity for highly efficient neutralisation together with a very low dissociation constant (close to 10 pM).
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