Sentence examples for neutral variant from inspiring English sources

Hence, students witness the selective sweep of the advantageous red eye phenotype, the hitchhiking of a nearby neutral variant (Fig. 2), and the lack of hitchhiking at a far-away neutral variant.

One can see that all red-eyed flies have the high band at the Near marker, illustrating the concept of a nearby neutral variant hitchhiking with an advantageous mutation (the red-eye color).

Students observe that most flies have red eyes, and these red-eyed flies have lost variation at the near marker but maintained variation at the far marker hence observing a "selective sweep" and the "hitchhiking" of a nearby neutral variant.

In this case, many recombination events occur when the allele(s) that will become selected sojourn(s) in the population as neutral variant(s).

Variants were most often located in exons 6, 9, and 11 (Table 2) but were absent in exon 1, 3, 5, 10, and 12. Eight novel RPGRIP1 variants were identified in 7 patients, including 7 pathogenic mutations and 1 putatively neutral variant.

Lastly, only 1/9 coding variants were of germline origin, vs. 7/7 noncoding variants, a difference that is statistically significant (p = 0.0014, Fisher's Exact Test) particularly since the single germline coding variant c.2077C>G (p.Phe354Leu) is a known non-pathological neutral variant present in normal individuals [16].

The explosion of deep sequencing and genotyping increasingly requires the distinction between effect and neutral variants.

Eventually, every individual in the population has the same mutation and the nearby neutral variants that "hitchhiked" with it.

Fig. 1 When an advantageous mutation occurs, it rises to high frequency, dragging along nearby neutral variants.

For example, when an advantageous mutation occurs, natural selection can push that mutation to high frequency, dragging along nearby neutral variants (Smith and Haigh 1974).

Conversely, neutral variants located far away from the advantageous mutation do not hitchhike because recombination can break apart the association and therefore maintain variation.