Sentence examples for neutral alterations from inspiring English sources
While a clonal population of tumor cells selects for changes conferring a growth advantage (driver), it also propagates non-functional (neutral) alterations.
Let us first investigate the level of heterogeneity of a population of type A tumor cells with growth rate R and death rate D, in which neutral alterations arise with probability u per cell division.
Until the breakthrough of NGS, the highest resolution for identifying copy number variations was achieved through microarray-based methods, which could detect amplifications and deletions in cancer genomes, but could not discern copy neutral alterations such as translocations or inversions.
Further, microarray-based analysis will not detect genomic alterations that do not result in changes in the amount of genetic material (copy neutral alterations), such as balanced translocations and inversions.
This approach is widely used to identify net CNAs targeting cancer-related genes but does not identify copy number neutral alterations that could be approached by screening for LOH using, e.g. SNP arrays.
The low-temperature neutral alteration might be locally distributed at shallow levels.
Likewise, the M1149V variant is predicted to be a neutral alteration that has little clinical significance.
Mutations are a source of genetic variation that confers to an organism either advantage due to a beneficial change, disadvantage due to a deleterious alteration, or neither due to a neutral change.
In a study of 36,325 patients with idiopathic ID, 0.78% of individuals were found to carry copy-number-neutral genomic alterations.
In general, p53 mutants may be classified according to their functional alterations: neutral, negative, dominant-negative or gain-of-function [ 32].
Mutations that change these positively charged amino acids to neutral ones result in alterations to the kinetics of voltage-dependent activation, observed as a shift in steady state activation toward more depolarized voltages.
