Sentence examples for neurotoxic function from inspiring English sources

We suppose that this weak neurotoxic function may have some synergistic effect with other neurotoxins in the venom, but it need to be proved by experiment data.

One of the concerns is that these agents may not target the NFT pathology and strong evidence has implicated a neurotoxic function of NFTs in Alzheimer's disease and other neurodegenerative diseases.

Thus, a polyQ-associated gain of neurotoxic function(s) conferred to these proteins is causative for these NDs (6); for example, the elongated polyQ tract acquires aberrant conformations, which may misfold the mutant proteins, generating species toxic to cells (motoneuron or muscle in SBMA); these species aggregate and form intracellular inclusions.

Tissue-type plasminogen activator (tPA) is a pleiotropic serine protease of the central nervous system (CNS) with reported neurotrophic and neurotoxic functions.

These neurotoxic functions are perhaps not surprising given that the primary role of these venoms is to paralyse or kill envenomated prey [ 11, 16, 17].

We performed pharmacophore perception to search for other naturally occuring peptides that are chemically related to these neuropeptides to determine if they exhibit similar neuro-protective or neurotoxic functions.

The level of GFAP upregulation in astrocytes has been reported to be dependent on both the brain region and the context, which could in part underlie the heterogeneity of functions mediated by astrocytes in the central nervous system, evidenced by their diverse neuroprotective or neurotoxic functions across different stages in AD [ 49].

Because foxo overexpression under the bursicon-Gal4 driver and all other IIS manipulations with the ccap-Gal4 driver (below) did not result in substantial cell loss, we did not determine whether the loss in ccap>FOXO animals was due to possible neurotoxic functions of FOXO (Kanao et al., 2010; Siegrist et al., 2010).

Overall our data reveal a critical neurotoxic effector function for mFasL and neuroprotective function of sFasL.

Based on a number of recent in vitro and in vivo studies, both neurotoxic gain-of-function and loss-of-function mechanisms have been proposed linking TDP-43 proteinopathy to neuropathology [6], [7].

Thus, our results of impaired neurogenesis in Faah−/− support the notion that high levels of AEA might be neurotoxic to NPC functions.