We found homogenous DREAM immunoreactivity in the cytoplasm of some neurons and in the neuronal nuclei of fresh TG (Additional file 3: Figure S3a).
For example, selective deletion from astrocytes of either the endoribonuclease, Dicer, or of the Wnt-signalling pathway gene, APC (adenomatous poliposis coli), in both cases leads to cell-non-autonomous neuronal degeneration of cerebellar Purkinje neurons and in the case of Dicer, also of cerebellar granule neurons (Tao et al., 2011; Wang et al., 2011a).
Brain-derived neurotrophic factor (BDNF) is a member of the neurotrophin family implicated in the survival and differentiation of neurons and in the outgrowth and pruning of neuronal processes (Lewin and Barde 1996; Lindsay 1996; Horch 2004).
Arque, G., Casanovas, A. & Dierssen, M. Dyrk1A is dynamically expressed on subsets of motor neurons and in the neuromuscular junction: possible role in Down syndrome.
But voxels are much larger than neurons, and, in the long run, the best way to understand the brain is probably not by asking which particular voxels are most active in a given process.
All studied iRFPs exhibited efficient binding of the endogenous biliverdin chromophore in cultured neurons and in the mammalian brain and can be readily applied to neuroimaging.
Chronic pain syndromes are etiologically connected to functional changes (sensitization) in both peripheral sensory neurons and in the central nervous system (CNS).
Exposing rats to heavy particles produces alterations in the functioning of dopaminergic neurons and in the behaviors that depend upon the integrity of the dopaminergic system.
A polycistronic GFP reporter under the control of the npr-22 promoter revealed expression in a few pairs of head neurons and in the intestine, but not in other tissues including muscle and hypodermis (Fig. 7b).
Hyman, B.T., Wenniger, J.J. & Tanzi, R.E., Nonisotopic in situ hybridization of amyloid precursor protein in Alzheimer's disease: Expression in neurofibrillary tangle bearing neurons and in the microenviroment surrounding senile plaques.
Together, our work indicates that hair-cell ribbon size influences the spontaneous spiking and the precise encoding of stimulus onset in afferent neurons.SIGNIFICANCE STATEMENT Numerous studies support that hair-cell ribbon size corresponds with functional sensitivity differences in afferent neurons and, in the case of inner hair cells of the cochlea, vulnerability to damage from noise trauma.
