Sentence examples for neuronal transfer from inspiring English sources

Such smoothness is expected to stem from the smoothness of the spatial inputs and of the neuronal transfer function.

The mechanisms responsible for the trans-neuronal transfer of PRV-Bartha are incompletely understood.

These data suggest that trans-neuronal transfer takes between 8 and 12 h, both for motoneuron to interneuron and then from interneuron to interneuron.

Therefore, understanding how inter-neuronal transfer of tau occurs may provide potential therapeutic targets to interrupt the proliferation of tau pathology early in disease.

However, in two lines of transgenic mice overexpressing a single isoform of mutant tau (P301L), known to cause fronto-temporal dementia, inter-neuronal transfer of mutant tau appears to occur before any marked neurodegeneration [ 5, 6].

Additional work is needed to determine whether tau can stimulate these receptors in vivo, as these studies suggest that, although inhibition of tau release may halt inter-neuronal transfer of tau pathology, care must be taken to ensure that normal functions of extracellular tau are preserved.

It is also unclear if neuronal death or injury is required for neuron-to-neuron transfer.

These properties have made HSV an excellent candidate for neuronal gene transfer.

Klein, R. L. et al. Efficient neuronal gene transfer with AAV8 leads to neurotoxic levels of tau or green fluorescent proteins.

Due to the heterogeneous cellular composition of the brain, cell-type-specific recombinant gene expression is required for many potential applications of neuronal gene transfer.

In vivo models of tauopathy suggest that inter-neuronal tau transfer might occur trans-synaptically [ 5, 6].