In order to determine if Aβ can induce changes in neuronal synchronization, the activities of pyramidal neurons were recorded in rat prefrontal cortical (PFC) slices under calcium-free conditions using multi-neuron patch clamp technique.
We suggest that group differences, showed in the ReHo analysis, reflect limited regional neuronal synchronization in (C APD, which might mean that detected neurons do not behave in a coherent fashion during rest.
Neuronal synchronization was identified according to the coordinated occurrence of responses between multiple neurons.
Many studies suggest an underlying correlation between neuronal synchronization and seizure development and onset [36, 37].
During NonREM there are several physiological changes which have neuronal synchronization as substrate; during REM the tendency is the opposite.
Moreover, this impaired sleep dependent memory performance was associated with reduced slow wave derived measures of neuronal synchronization.
Structurally, this situation is analogous to the kind of mixed common-noise and independent-noise scenario studied in the context of neuronal synchronization [56 58].
The model also substantiates that impairments in neuronal synchronization – as found in ASD – reduce the emergence of global structures and, thereby, their masking effect on incompatible features.
It will be shown that the tools of nonlinear dynamics can be irreplaceable for revealing hidden mechanisms subserving, for example, neuronal synchronization and periodic oscillations.
Indeed, beyond the reservations that one may have concerning the variable quality of the output of such software, the use of clean original electrophysiological signals makes safer the more specific study of precise neuronal synchronization.
Phase-resonance has also been investigated in neuronal systems [11, 14, 29], although to a lesser extent than subthreshold resonance, and it has been proposed to play an important role in neuronal synchronization [30].
