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Does the non-learner group also exhibit neuronal sequences bridging the CS and US?
How do we know the neuronal sequences in CA1 bear any meaning to this task?
Many possible different neuronal sequences can occur within each of the 7-8 frames composing the 600 ms interval between CS and US.
This further extends the recent findings that pre-existing neuronal sequences may influence future memory codes (Gupta et al., 2010; Dragoi and Tonegawa, 2011).
Does the non-learner group also exhibit neuronal sequences bridging the CS and US? 11) How do the authors explain that the noise correlations (NC) declined toward the end of the session?
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Skaggs, W. E. & McNaughton, B. L. Replay of neuronal firing sequences in rat hippocampus during sleep following spatial experience.
"Temporally precise sequences of neuronal spikes that span hundreds of milliseconds are observed in many brain areas, including songbird premotor nucleus, cat visual cortex, and primary motor cortex.
Of note, the decrease in editing levels was consistent among different Alu sequences during neuronal differentiation (Figure 2A).
Subsequently, these sequences of neuronal activity are replayed in association with hippocampal sharp wave-ripple (SPW-R) events of quiet wakefulness and sleep (O'Keefe and Dostrovsky, 1971; Lee and Wilson, 2002; Foster and Wilson, 2006; Diba and Buzsáki, 2007).
DOI: http://dx.doi.org/10.7554/eLife.03542.002 Cognitive processes are thought to involve the organization of neuronal activity into phase sequences, reflecting sequential activation of different cell assemblies (Hebb, 1949; Harris, 2005; Buzsáki, 2010; Wallace and Kerr, 2010; Palm et al., 2014).
Here, we note that calcium response recordings typically have a time resolution of about 100 ms, a time window within which entire sequences of neuronal activation have been known to occur (Foster and Wilson, 2006).
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