Exact(27)
In cultured neurons, the lactate dehydrogenase isoenzyme pattern was not altered by medium glucose level (5.5, 13.4 or 26.8 mmol/l; O'Brien et al., 2007), but Kleman et al. (2008) emphasize the negative effects of high glucose levels on the viability of cultured neurons and neuronal responsiveness to the AMPK (AMP-activated protein kinase) energy signalling system.
The behavioral state-dependent bidirectional modulation of neuronal responsiveness in L5B pyramidal neurons (i.e., increased or decreased spike probability) could facilitate the routing of sensorimotor information through specific M1 neuronal assemblies during movement.
Altogether these data suggest a complex "permissive-integrative" role on neuronal responsiveness in order to shape neurons spectral and temporal features.
The present study demonstrates, for the first time, that PM2.5 exposure reduces neuronal responsiveness to excitation in anatomically identified cardiac vagal neurons in the NA.
Prolonged or strong activity of dorsal horn neurons caused by repeated or sustained noxious stimulation may subsequently lead to increased neuronal responsiveness or central sensitization [ 25, 27].
Uwano, T., Nishijo, H., Ono, T. & Tamura, R. Neuronal responsiveness to various sensory stimuli and associative learning in the rat amygdala.
Similar(33)
At the neuronal level, repeated or prolonged exposure to a stimulus (adaptation) is classically known to reduce the neurons' responsiveness to the same stimulus.
However, such gains in neuronal plastic responsiveness come at a price: a protein synthetic machinery that, unless properly controlled, may engage in premature or inappropriate translation of locally available mRNAs, resulting in neuronal hyperexcitability.
Nano-meshworks of single-walled carbon nanotubes (SWNTs) and MWNTs on glass slides have been shown to support neuronal growth and responsiveness of rat hippocampal neurones.
Noradrenaline, released during this high level of LC activity, should enhance neuronal excitability and responsiveness to depolarizing inputs through action at beta-adrenergic receptors [36].
Ascorbate improved microcirculatory perfusion by NOX inhibition and arteriolar vasodilator responsiveness (neuronal nitric oxide synthase related), restored vasoconstrictor responsiveness by inhibiting iNOS expression and prevented vascular leakage.
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