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The training leads to sharp individual neuronal reactions, neurons become specific to one pattern.
At the beginning, neuronal reactions are chaotic.
For that reason, physiological adaptations that are observed at the hypometabolic state in hibernation are potentially analogous to neuronal reactions to a hypometabolism in very early stages of AD.
The neuronal reactions for HNE and MDA in idiopathic autism were stronger than in control brains.
In dup(15)/autism the neuronal reactions for MDA were stronger than in control brains and in idiopathic autism.
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Habituation, as a basic form of learning, is characterized by decreasing amplitudes of neuronal reaction following repeated stimuli.
Fast and precise neuronal reaction requires that SVs are clustered in front of the release site, the presynaptic active zone.
With time these lesions evolve into chronic lesions that exhibit a glial and microglial reaction as well as a neuronal reaction which includes thinning of dendrites in the adjacent tissue.
Double immunostaining for Aβ and HNE in dup(15)/autism revealed stronger neuronal HNE reactions than in control brains and in idiopathic autism.
The upregulation of NOS in our study most likely represents a neuronal plasticity reaction to SAP.
In the present study, we also found thapsigargin induced the transcriptions of sod 1, sod 2 and cyt-c, which may be considered as the neuronal intrinsic protective reactions.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com