Since the first demonstration of exosome secretion by central neurons more than 10 years ago19, a few neuronal proteins have been shown to be secreted on exosomes including AMPA receptors (AMPARs), amyloid β, ephrins, and Arc20,37,38,39,40.
Although critical evolutionarily conserved functions for O-GlcNAc on neuronal proteins have been suggested, the roles of O-GlcNAc in living neurons are not clear.
These cells also expressed the mature neuronal proteins TUBB3 and HNCAM (Fig. 2i j).
For example, do T cells that target neuronal proteins other than hypocretin have a role in narcolepsy?
However, the physiological significance of these exosome-associated neuronal proteins in the vertebrate brain is poorly understood22.
This mechanism may be universal to anesthetic action on neuronal proteins.
Akchiche, N. et al. Homocysteinylation of neuronal proteins contributes to folate deficiency-associated alterations of differentiation, vesicular transport, and plasticity in hippocampal neuronal cells.
Collectively their data identify important roles for Fuc-α(1 2 Gal sugars in the regulation of neuronal proteins and morphological changes that may underlie synaptic plasticity.
Moreover, previous reports10,11 suggest that antibodies targeting neuronal proteins are present at a higher than usual frequency in people with narcolepsy.
This direct regulation of the protein synthesis machinery helps explain the observation that activation of MAPK enhances the production of a broad range of neuronal proteins.
Secondly, differential expression levels of the genes encoding neuronal proteins were analyzed to study odontoblasts sensory function.
