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The underlying cellular defects appear to be related to improper neuronal migration during early prenatal development.
Human neurological conditions associated with abnormal neuronal migration, together with spontaneous and engineered mouse mutants, define at least four distinct steps in cortical neuronal migration.
Several proteins and pathways have been identified as mediators of developmental neuronal migration and cell positioning.
Protocadherins (PCHD) are cell adhesion proteins with an important role in neuronal migration, differentiation and synaptogenesis.
The development of the mammalian brain is dependent on extensive neuronal migration.
Alterations of cortical neuronal migration and cerebellar Purkinje cells have been observed in autism.
Correct neuronal migration is crucial for the brain architecture and function.
Many genes associated with neuronal migration and stem cell differentiation were significantly up-regulated.
Thus, LIS1-mNudE interactions may regulate neuronal migration through dynamic reorganization of the MTOC.
Fœtal pathologic findings revealed anomalies in neuronal migration and in the vascular architecture in the brain.
Doublecortin (DCX) is a microtubule (MT -stabilizing protein essential for neuronal MT -stabilizingg human brain developrotein
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