Sentence examples for neuronal lines from inspiring English sources
Future studies utilizing induced pluripotent stem cells (iPSCs -derived neuronal liPSCs -derivede editineuronalISPR/Cas9, wilineslow us to vanddate, characterize, and manipulate the effects of particular cis-genomec variants on SNCA editingion.
A few studies have shown that DNA methylation of the NEP promoters do not mediate its transcriptional repression in the neuronal lines [36] or in hepatobiliary cells in Alagille syndrome [37].
Particularly, the five TS neuronal lines all tightly clustered together.
This may suggest that these genes are less important for AD pathogenesis as their expression varies among different neuronal lines.
> In all neuronal lines, the Ca2+ response to a single brief application of glutamate was variable from cell to cell (Fig. 3), suggestive of heterogeneity within the populations.
Total RNA was isolated from 4 weeks differentiated neurons of two controls (CTRL-1, CTRL-2) and two SPG11 patients (SPG11-1, SPG11-2) neuronal lines using RNAeasy mini kit (Qiagen).
In accord with their structure-activity relationship in the primary screen, the best "hits" stabilize HIF1α, upregulate known HIF target genes in a human neuronal line, and exert neuroprotective effects in established model of oxidative stress in cortical neurons.
In a striatal neuronal line obtained from HD knock-in mice (HdhQ111/Q111) [34], we find that etoposide treatment also promotes cleavage of full-length, mutant Htt protein (Fig. 7, top panel, lane 2).
Corroborating studies reported supportive effects of sunitinib on embryonic cortical neurons, cerebellar neurons, neuronal cell lines, and astrocytes when compared to standard culture conditions.
Here we show that the principal PINK1 and Parkin cellular events that have been documented in non-neuronal lines in response to mitochondrial damage also occur in primary neurons.
Epub 2014 Sep 12. Gibson GE, Xu H, Chen HL, Chen W, Denton TT, Zhang S. Alpha-ketoglutarate dehydrogenase complex-dependent succinylation of proteins in neurons and neuronal cell lines.
