This intimate relationship between GABAergic interneurons, pyramidal neurons and neuronal input from the MDTN, suggests that the functional impairment of any one of these cell types could cause dysregulation of excitatory input and output from this brain region.
We found that when the stimulus offset was relatively small in comparison to the neuronal input conductance (see Methods), some neurons were able to fire at low frequency but decreased their response rate as the stimulus frequency increased (Fig. 1B, blue line).
The findings suggest that the βM CaMKII isoform of skeletal muscle does, like the αCaMKII isoform in neurons, act as a decoder of neuronal input [ 25]. βM CaMKII regulates calcium release from the sarcoplasmic reticulum [ 7, 14] whereas the δA CaMKII isoform has been demonstrated to affect nuclear processes and modify cardiac growth [ 22, 23].
In order to explore whether the spatiotemporal patterns of the inputs was necessary for the neuronal input segregation, we also investigated for a subset of the neurons the neural responses to spatial and temporal shuffling, respectively, of the stimulation patterns.
We describe three slow muscles that responded to low-frequency modulation of a high-frequency neuronal input and, consequently, could express the motor patterns of neural networks whose neurons did not directly innervate the muscles.
Although the aBoc and Emc steps of this cycle require neuronal activity via a GABAergic motor neuron the pBoc step and initiation of the defecation cycle do not require neuronal input [45].
Lovett-Barron, M. et al. Regulation of neuronal input transformations by tunable dendritic inhibition.
Morris, L. G. & Hooper, S. L. Muscle response to changing neuronal input in the lobster (Panulirus interruptus) stomatogastric system: Spike number vs. spike frequency dependent domains.
This article examines endophenotypes for temporal coding in schizophrenia, centring on aberrant, neuronal, input connectivity to the cerebellum.
Light is considered the dominant time-giver responsible for the entrainment of circadian rhythms and the only one for which detailed characterization of the molecular and neuronal input pathways is available for both insects and vertebrates40,41,42.
Although the generation of the pacemaker activity per se does not depend on neuronal input, its modulation, for instance the speed and amplitude of the bursts, is under neuronal control2.
