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However, kinase activity is necessary for asymmetric neuronal division (Forrester et al., 1999).
Because each fluorescence spot is supposed to be a trace of an initial sensory organ precursor (SOP), these data argue in favor of a heterogeneous process of neuronal division in the adult Drosophila wing before the sensory organs are completed.
In the external fork of the anterior wing margin, clusters with two or four fluorescent cells were observed, which is in accordance with neuronal division in multiple innervated chemoreceptors.
We propose that the abnormal motility and defective neuronal division observed in Lis1 RNAi [ 21] emerge from a delay in the multipolar stage.
The reason for the absence of neuronal division and, indeed, tumors of neuronal origin, would simply reflect the impossibility of a fully mature neuronal cytoskeleton to revert to a mitosis-ready configuration.
According to the protomap model, the transcriptional fate, and thus the areal blueprint, is already determined at the time of the last neuronal division rather than by the ingrowth of thalamic fibers.
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Consistently, we found that fzy-1(h1983) did not affect postembryonic neuronal cell division (Figure 8C).
It is believed that, during adulthood, neuronal cell division can only take place in the subventricular zone and subgranular zone of the human hippocampus [ 25].
Methylmercury is believed to inhibit those processes in the brain specially involved in development and growth such as neuronal cell division and migration.
Ethanol exposure also alters the rate of neuronal cell division in the immature brain, reducing the number of new cells as well as deterring neural outgrowth (Guerri, 1998).
These findings have led to speculate that, in the absence of detectable neuronal cell division, there may be additional, cell cycle independent roles for cell cycle regulators in adult neurons.
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